Unanchored ubiquitin chains
Web1 Jan 2014 · Selective purification of unanchored polyubiquitin chains using the Znf UBP (BUZ) domain of USP5/isopeptidase-T allowed the isolation of K48 and K11-linked ubiquitin dimers, as well as revealing ... WebDepartment of Microbiology and Immunology RESEARCH ACTIVITIES: (2024-Present) Graduate student collaborator with Dr. Ricardo Rajsbaum PhD: NIH Grant: “Unanchored Polyubiquitin Chains and Innate ...
Unanchored ubiquitin chains
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Web7 Feb 2024 · This confers the capacity to specifically recognize free ubiquitin chains, which may be derived from newly synthesized linear ubiquitin or from chains that have been … Web24 Oct 2016 · TRIM25 produces unanchored ubiquitin chains that activate RIG-I in vitro , suggesting that interaction with unanchored ubiquitin might regulate duck RIG-I. Adaptation of IAV strains to counteract different immune responses in avian and human hosts likely contributes to interspecies transmission and pandemic risk. 9. Ubiquitin Regulates ...
WebSelective purification of unanchored polyubiquitin chains using the Znf UBP (BUZ) domain of USP5/isopeptidase-T allowed the isolation of K48 and K11-linked ubiquitin dimers, as well … Web4 Jun 2010 · It has become increasingly clear that cellular proteins can become conjugated with chains of the small protein ubiquitin without becoming degraded by the proteasome. …
Web10 Aug 2010 · Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as … Web24 May 2024 · Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF-κB Signaling Cells June 22, 2024 See publication. Expanding Role of Ubiquitin in Translational ...
Web22 Jun 2024 · cells Article Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF- B SignalingJessica R. Blount 1, Kozeta …
Web7 Sep 2010 · DUBs vary in their preference for cleaving ubiquitin chains of different linkages types, their preference for substrate-bound ubiquitin chains as opposed to unanchored (free) ubiquitin chains, and their cellular localization . Some DUBs appear to function with high specificity toward one or a few substrates, although only a few examples of this are … rayna mill creek facebookWeb4 Jun 2024 · An unanchored polyubiquitin chain is a free ubiquitin chain that is not conjugated to a substrate protein. Knowledge of the range of fundamental processes that may be regulated by unanchored polyubiquitin and unanchored phosphorylated-polyubiquitin chains, as well as the precise molecular composition of these ubiquitin polymers (i.e., … rayna northcuttWebUbiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a … rayna peacock swivel glider power reclinerWeb12 Oct 2024 · Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains. Bin Song, Yun Chen, Xin Liu, Fei Yuan, ... Jie Zheng. Pages 2218-2230.e5 View PDF. Article preview. rayna novash deathWeb30 May 2024 · Europe PMC is an archive of life sciences journal literature. raynan lynn cravey texasWeb19 Jun 2014 · TRIM6 and the E2-ubiquitin conjugase UbE2K cooperated in the synthesis of unanchored K48-linked polyubiquitin chains, which activated IKKε for subsequent STAT1 … ray nancarrowWebUSP4 and ovarian tumor-domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) stabilize RIG-I proteins by eliminating the K48-linked ubiquitin chains conjugated to RIG-I. 225,226 ... ray napper welland