WebJun 2, 2015 · The nanomolar affinity of TUBEs for poly-ubiquitinated proteins allows the efficient isolation and identification of ubiquitinated proteins from cells, tissues and organs. To learn more about TUBEs, their benefits and potential applications TUBEs (WB, pull downs, histochemistry, fluorescence microscopy), take a look at TUBEs – efficiently detect & … WebApr 9, 2015 · Traditional methods to detect and purify poly-ubiquitinated proteins require either anti ubiquitin antibodies or Ubiquitin Binding Associated domains (UBAs) which …
Ubiquitin Antibody Cell Signaling Technology
WebJan 28, 2024 · Lys 63 ubiquitin chains are conjugated to Lys13-15 mono-ubiquitinated H2A/H2AX and the resulting poly-ubiquitinated histones facilitate the DNA damage response (DDR) . 53BP1 is a chromatin-associated factor that promotes DSB repair by nonhomologous end joining. 53BP1 binds mono-nucleosomes including demethylated … WebThe proteasome is a ubiquitous multi-subunit enzyme complex that plays a critical role in the degradation of poly-ubiquitinated proteins to produce small peptides. 6 Ubiquitin-independent proteasomal degradation has also been reported, provided that the target contains intrinsically disorganized regions. 7 Many subunits of the proteasome are ... dvd shopping india
RAD18 mediates DNA double-strand break-induced ubiquitination …
WebIt is important to distinguish between poly-ubiquitination and multi-mono-ubiquitination because these different types of ubiquitination lead to different functions of the substrate … WebApr 27, 2024 · Firstly, the local concentrations of p62 body scaffolds (i.e., p62 and poly-ubiquitinated protein) in normal cells are below the critical concentrations for phase separation. Secondly, ... WebDownload scientific diagram H2AX Is Stabilized in Response to DSBs through ATM Activation with the Resulting Attenuation of the Poly-ubiquitinated H2AX and HUWE1 Complex from publication: ATM ... dvd shopping comparison