Plk4 cancer

Author: wxey

August undefined, 2024

WebbPolo-like kinase 4 (PLK4), a unique member of the polo-like kinase family of serine-threonine kinases, is a master regulator of centriole duplication that is important for maintaining genome integrity. Overexpression of PLK4 is found in several human cancers and is linked with a predisposition to tumorigenesis. Previous efforts to identify potent … Webb10 apr. 2024 · PLK4 . Another potential drug class was developed with potential synergy with immunotherapy, according to Gautam Borthakur, MD, a Professor in the Department of Leukemia at the University of Texas MD Anderson Cancer Center. PLK4 is a novel target of interest in the management of leukemia.

Reversible centriole depletion with an inhibitor of Polo-like ... - Science

Webb1 jan. 2024 · PLK4 regulates multiple cellular biological processes and is implicated in tumorigenesis. Dysregulation of PLK4 leads to a predisposition towards cancer … WebbDeregulated PLK4 activity plays a prominent role in cancer and metastasis. Several PLK4 inhibitors with anticancer activity are in pre-clinical stage and a single inhibitor, CFI-400945 has entered clinical phase. Further research should focus on finding safer and more effective drugs at clinical stage, based on a better understanding of PLK4. decorative bubble ceiling light

PLK4: a promising target for cancer therapy - PubMed

Webb23 juni 2024 · Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, has recently been shown to play key roles in tumorigenesis. Blocking PLK4 expression by … Webb15 juli 2013 · The Plk4 binding regions of Cep192 and Cep152 (residues 190–240 and 1–46, respectively) are rich in negatively charged amino acids, suggesting that Plk4 localization to centrioles depends on electrostatic interactions with the positively charged polo-box domain. WebbPLK4 was also identified as a potential therapeutic target for malignant rhabdoid tumors, medulloblastomas and possibly, other embryonal tumors of the brain. Interactions and … federal grants for volunteer fire departments

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TEC kinase stabilizes PLK4 to promote liver cancer metastasis

Webb25 mars 2024 · It is well known that PLK4 localizes to centrioles and coordinates duplication of centrioles in the late G1 and early S phases of the cell cycle. 9, 10 Increased PLK4 expression has been associated with poor outcomes in several human cancers, including colorectal, 11 breast, 12, 13 melanoma, 8 and neuroblastoma. 14 Proper … WebbPolo-like kinase 4 (PLK4) is a cell cycle-regulated protein kinase (PK) recruited at the centrosome in dividing cells. Its overexpression triggers centrosome amplification, which is associated with genetic instability and carcinogenesis. In previous work, we established that PLK4 is overexpressed in pediatric embryonal brain tumors (EBT). decorative broomsticksWebbIn addition, PLK4 was overexpressed in human PCa cell lines and tumors. Moreover, PLK4 inhibitors CFI-400945 and centrinone-B inhibited cell growth, viability, and colony … decorative brightest light bulbs

"Webbtumor growth suppression.16 Besides, PLK4 is crucial to PTEN-de cient cancer cells for survival suggesting that there is a synthetic lethal interaction between PLK4 and PTEN in breast cancer cells.17,18 Thus, PLK4 could be a potential target for breast cancer and draw our attention to discover PLK4 inhibi-tors as candidates against breast cancer. " - Plk4 cancer

Plk4 cancer

PLK4: a link between centriole biogenesis and cancer

Webb5 nov. 2024 · Introduction: CFI-400945 is a first-in-class, potent, selective, orally active inhibitor of Polo-like kinase 4 (PLK4) (Ki=0.26nM), a master regulator of centriole … Webb9 sep. 2024 · CFI-400945 is a PLK4 inhibitor that also targets aurora B, and is in clinical trials as a therapeutic agent for patients with breast cancer 20,21,22. We therefore tested the effect of CFI-400945 ...

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Webb1 mars 2024 · We show that by targeting a centrosome regulator, PLK4, to activate the cytosolic DNA sensing-mediated immune response, CFI-400945 effectively restrained … WebbPatients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent. Read more. PLK4 is not prognostic in prostate cancer. Alive (n=484)

Webb1 apr. 2024 · The important role of PLK4 in centrosome biology coupled with its demonstrated connection with cancer development and progression signaling provides … Webb6 sep. 2024 · The critical role of centrosome amplification and PLK4 in cancer is summarized and recent advances in the development ofPLK4 inhibitors are highlighted, suggesting a potential therapeutic strategy for cancer. Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase that regulates centriole duplication. PLK4 deregulation …

WebbExpression of PLK4 (Sak, STK18) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability of our website. If you continue, we'll assume that you … WebbTraductions en contexte de "thérapie et de diagnostic du cancer" en français-anglais avec Reverso Context : La présente invention a pour objet général de nouveaux composés phospholipides deutérés, des compositions comprenant ces composés, et leur utilisation dans diverses applications de thérapie et de diagnostic du cancer.

Webb1 jan. 2024 · Aberrated PLK4 expression has been reported in different malignancies and causes centrosome amplification, aneuploidy, and genomic instability. However, the …

Webb1 dec. 2015 · 2.1. Elevated Plk4 expression dramatically advances the onset of tumour formation in p53-deficient mice. Centrosome amplification has been identified as a marker of poor prognosis of aggressive, drug-resistant tumours in breast, pancreatic and colorectal cancer patients [43,44], but the relationship of centriole amplification to … decorative buckles for bootsWebb12 mars 2024 · Plk4 has been identified as a master regulator of centriole replication, and its aberrant expression is closely associated with cancer development. In this review, … decorative brooch pinsWebb24 maj 2024 · Polo-like kinase 4 (PLK4), a vital regulator of centriole duplication, is important for maintaining genome stability. Dysregulation of PLK4 has been found in several human cancers and is associated with a predisposition to tumorigenesis. Herein, we describe the discovery of (E)-4-(3-arylvinyl-1H-indazol-6-yl)pyrimi federal grants for universitiesWebb20 feb. 2024 · Polo-like kinase 4 (PLK4) is a serine/threonine kinase regulating centriole duplication. CFI-400945 is a highly selective PLK4 inhibitor that deregulates centriole … federal grants in aidWebbPLK4. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … federal grants for women over 60Webb1 sep. 2014 · Polo-like kinase 4 (PLK4) is a mitotic kinase that regulates centriole duplication. PLK4 depletion arrests centriole duplication and has been shown to have a synthetic lethal interaction with PTEN deficiency, suggesting PLK4 may be … decorative brown hand towelsWebbPhysician, Scientist, and Medical Affairs Specialist with extensive experience in cancer diagnosis and in identifying and validating new biomarkers and therapeutic targets in oncology. In Medical ... decorative building blocks for garden