Phosphopantetheine binding acp domain
WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier … Webthe S. cerevisiae FAS (19, 20), the missing ACP domain was subsequently located, docked to the KS domain. We have recently purified the S. cerevisiae fatty acid synthase ... third part binding the CoA or ACP phosphopantetheine group that transfers the acyl and malonyl substrates. In the large fungal fatty acid complex, the KS dimers were ...
Phosphopantetheine binding acp domain
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WebChr: 1 Mapping Details/Browsers Description Predicted to enable acyl binding activity and acyl carrier activity. Predicted to act upstream of or within fatty acid biosynthetic process. … WebJul 31, 2014 · (1) Movement of the ACP’s phosphopantetheine (Ppant) arm is thought to be coordinated with protein–protein interactions and significant rearrangement of the PKS enzyme assembly. (2-5) The dynamic structures of ACPs and their Ppant arms are difficult to track due to the flexibility of ACPs and ACPs’ transient interactions with catalytic …
WebThis multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. 2 publications Catalytic activity WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty … Hei Sook Sul, ... Li Chen, in Progress in Nucleic Acid Research and Molecular …
WebThe phosphopantetheine-attachment site (ACP4: S46 and ACP3a: S62) is highlighted with an asterisk. ... The KR-binding epitope of the ACP domain encompasses key residues situated on H I and H II, and combined with previous observations, 17 the ACP domain docks at the same KR C subdomain site in both cis- and trans-AT systems. WebMar 2, 2010 · 7 malonyl-CoA + hexanoyl- [acyl-carrier protein] = 7 CoA + norsolorinate anthrone + [acyl-carrier protein] + 7 CO (2) + 2 H (2)O. Biochemical function: not assigned. …
WebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production.
WebJul 22, 2015 · Acyl carrier protein (ACP) Phosphopantetheine binding ACP domain; Structure analysis Details. Assembly composition: monomeric . Entry contents: 1 distinct polypeptide molecule ... Sequence domains: Phosphopantetheine attachment site. Ligands and Environments No bound ligands. No modified residues. fkhinfo firstkeyhomes.comcannot hold peeWebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty acids (FAs) (use ACPs) ( Scheme 23 ), polyketides (PKs) (use ACPs) ( Scheme … fkh nedirWebApr 20, 2024 · ACP-like superfamily, phosphopantetheine binding ACP domain, trimeric LpxA–like superfamily, AMP-dependent synthetase–like superfamily, polyketide synthase, phosphopantetheine-binding domain, AMP-dependent synthetase/ligase: −1.20: −2.32: −1.12: 0.117796: 0.537084: g11299: fkh matthewWebOct 5, 2001 · B. subtilis AcpS and its substrate ACP were biochemically characterized. AcpS also modified the d-alanyl carrier protein but failed to recognize PCP and an acyl carrier … can not hold peeWeb210-kDa -chain contains a KS domain, a ketoacyl reductase (KR), and a phosphopantetheine transferase domain. In addi-tion, the -chain includes an N-terminal ACP, required for the … fkh landscapesThe acyl carrier protein (ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. It is one of the most abundant proteins in cells of E. coli. In both cases, the growing chain is bound to the ACP via a thioester derived from the distal thiol of a 4'-phosphopantetheine moiety. cannot hold my urine female