Phosphopantetheine attachment site
WebSep 1, 2000 · Motifs I and III have been associated with ATP-binding and hydrolysis activities, respectively, since motif X contains a conserved serine to which a 4′-phosphopantetheine cofactor is very probably attached [ 3 ]. Weband acyl carrier protein [also known as a phosphopantetheine attachment site (PP) domains]. The KS, AT, and PP domains are essential for both FASs and PKSs, whereas the KR, DH, and ER domains are present in all FASs, but some or all are absent in various PKSs. KR, DH, and ER domains catalyze, in a stepwise
Phosphopantetheine attachment site
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WebDefinition: Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis. ID: GO:0000036 Synonyms: Articles referencing this term. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork ... WebFeb 20, 2024 · In addition, the phosphopantetheinylation of ACPs is dependent on the co-enzyme A, the PPT enzyme and the conserved serine residue in the phosphopantetheine attachment site (Supplementary Fig. 3 ...
http://amigo.geneontology.org/amigo/term/GO:0000036 WebJul 17, 2024 · The PCP Ser702, which serves as the phosphopantetheine attachment site, is positioned 52 Å away from the bound AMP phosphate. By contrast, ...
Webreductase; KR, ketoreductase; PP, phosphopantetheine attachment site (acyl carrier pro-tein of PKSs and thiolation of NPSs); AMP, adenylation; CON, condensation; HGT, horizon-tal …
WebThe human NDUFAB1 protein contains a phosphopantetheine attachment site (DLGLDSLDQVEIIMAM), unique for acyl carrier proteins, and an EF-hand calcium binding domain (DIDAEKLMCPQEI). Transcripts of this gene are found in …
WebMar 21, 2024 · This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ( [ACP]) domain. ( FAS_HUMAN,P49327 ) (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. ( FAS_HUMAN,P49327 ) how to see bios windows 10WebMar 23, 2024 · It has 12 putative transmembrane domains and intracellular N and C termini. SLC26A1 contains a sulfate transporter signature, a phosphopantetheine attachment site, … how to see bios version msiPhosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). It is also present in formyltetrahydrofolate dehydrogenase. how to see birthday on facebookhttp://pfam-legacy.xfam.org/family/PF00550 how to see bios version without restartingWebthis effect was dependent upon an intact phosphopantetheine attachment site (PPAS) motif within the α/β hydrolase fold of NDRG1. Materials and Methods. Cell lines and culture. BeWo, JEG-3, CHO, and NIH3T3 lines were purchased from ATCC (Manassas, VA) and cultured as we previously detailed [38-41]. We also previously characterized and detailed the how to see birthdays on snapchatWebAug 1, 2015 · Phosphopantetheine attachment site: Dieckmanna Cyclase (DKC) NADB-Rossmann: I3810-R4092: NAD(P)-binding motif: ORF3 (fumoA) encodes a cytochrome P450 monooxygenase which maybe catalyzes an unprecedented oxidative ring expansion of prefumosorinone A to form the 2-pyridone core of fumosorinone (Halo et al., 2008a). … how to see birthday posts on facebookWebACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process: Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis. GO:0009987: cellular process how to see birthday on instagram