WebThe Ras-GTPase activating protein SH3 domain-binding protein 1 (G3BP1) plays a critical role in the formation of classical and antiviral stress granules in stressed and virus-infected eukaryotic cells, respectively. While G3BP1 is known to be phosphorylated at serine residues which could affect stre … WebSep 29, 2024 · Depletion of G3BP1 significantly attenuated the activation of NF-κB signaling pathway. ... our results demonstrate that SVV induces transient SG formation in an eIF2α phosphorylation and PKR ...
G3BP1 G3BP stress granule assembly factor 1 [ (human)]
WebNational Center for Biotechnology Information WebApr 9, 2024 · This study also shows that SIRT6 influences the phosphorylation of G3BP1 at serine 149, but no . 400. differences were reported on the interaction between SIRT6 and G3BP1-S149A or S149E . 401. officer and a gentleman vs top gun
Arginine Demethylation of G3BP1 Promotes Stress Granule Assembly
WebSep 29, 2024 · Furthermore, we also found that 3C protease blocked the SG formation by disrupting eIF4GI-G3BP1 interaction. Overall, our results demonstrate that SVV induces transient SG formation in an eIF2α phosphorylation and PKR-dependent manner, and that 3C protease inhibits SG formation by interfering eIF4GI-G3BP1 interaction. WebApr 9, 2024 · Stress granules (SGs) are cytoplasmic, non-membranous RNA/protein structures that assemble in response to environmental stress. G3BP is a critical SG-nucleating protein, and its ability to regulate SGs has been reported to be regulated by serine 149 phosphorylation. We now report that the constructs engineered to contain … WebApr 11, 2024 · Protein kinases represent key regulatory elements of the mitotic cycle, transferring phosphorylation signals to critical effectors (Nigg, 2001). Polo-like kinase 1 ... cells synchronized in G1/S with DTB and transfected with the indicated flag-tagged UBAP2L constructs and control or G3BP1/2 siRNAs for 48 h. Proteins MW is indicated in kDa. WB ... mydcc account